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Smart-GI: AI-supported diagnostics and therapy in the GI tract


  • Endoscopic submucosal dissection (ESD) enables minimally invasive resection of large lesions and thus offers an organ-preserving alternative to surgical resection. However, ESD is a technically demanding procedure with considerable risks: The unintentional cutting of blood vessels prior to their coagulation can lead to severe bleeding, which not only impairs the surgeon's vision but can also endanger the patient.

    Our SmartESD deep learning system supports the surgeon by detecting and highlighting blood vessels in the endoscopic video image in real time. At the same time, the position of the dissection knife is continuously tracked. If the knife comes too close to critical structures such as blood vessels, the system proactively warns the surgeon.

    SmartESD thus acts as a vigilant surgical assistant that increases the safety of the procedure and can contribute to lower complication rates - particularly valuable in complex anatomical situations or during longer procedures where concentration can wane.


  • Endoscopic submucosal dissection typically goes through several defined phases: Diagnosis, marking, injection, dissection and hemostasis. The sequence, duration and frequency of these phases are characteristic of the course and quality of a procedure. While an ESD with few complications is characterized by few bleeding episodes and continuous dissection progress, frequent changes between dissection and hemostasis indicate technical difficulties or complications.

    Our deep learning system automatically recognizes these phases in the endoscopic video and thus creates a precise "fingerprint" of the procedure. This objective documentation enables a wide range of applications: Interventions can be compared and evaluated using quantitative quality metrics - for example, in terms of the total duration of bleeding phases or the efficiency of the dissection. For doctors in training, automatic phase recognition can make individual learning curves visible: With increasing experience, the quality metrics should continuously improve. In addition, particularly challenging ESDs can be identified so that they can be processed for training purposes.



  • Endoscopic retrograde cholangiopancreatography (ERCP) is a therapeutic procedure used to treat diseases of the bile ducts and pancreatic duct - for example to remove gallstones. The success of the procedure depends largely on the successful probing of the papilla vateri, the anatomical structure where the bile duct and pancreatic duct open into the duodenum. However, the anatomical shape of the papilla varies greatly between patients. Different morphological subtypes can make probing considerably more difficult, especially if mucosal folds partially cover the orifice (ostium). Multiple probing attempts increase the risk of serious complications, especially post-ERCP pancreatitis.

    Our deep learning system automatically recognizes the papilla vateri and its ostium in the endoscopic image. By precisely localizing even difficult-to-detect orifices, the system can provide the examiner with targeted support during probing and reduce the number of cannulation attempts. The long-term goal is to automatically assess the difficulty of probing based on the anatomical structure of the papilla. This enables individualized selection of the practitioner: while simple papillae can be treated by doctors in training, anatomically difficult cases are referred directly to experienced specialists. This pre-procedural risk assessment can reduce the number of unsuccessful cannulation attempts and thus significantly reduce the risk of complications for the patient.



  • Oesophageal reflux can lead to serious mucosal changes in the oesophagus. The transition from Barrett's oesophagus - a preliminary stage - to adenocarcinoma is particularly critical. During endoscopic examination, this differentiation is a challenging diagnostic task: the transitions are often fluid and the visual differences subtle, making it a challenge even for experienced gastroenterologists. While Barrett's esophagus requires regular monitoring, carcinoma requires immediate therapeutic intervention.

    Our deep learning-based system supports physicians in analyzing endoscopic images by reliably identifying and differentiating premalignant and malignant lesions. The neural network has been specially trained to recognize the subtle differences between Barrett's mucosa and adenocarcinoma. The system acts as an intelligent assistant, providing the examiner with a second opinion in real time and thus increasing diagnostic certainty.


      • Funding

        2020: Doctoral funding for Robert Mendel, funding program of the Bavarian State Ministry of Science and the Arts

      • Volume

        Project volume: approx. 281 T€

      • Funding

        2018: Funding program for applied research and development at universities of applied sciences - universities of applied sciences of the Free State of Bavaria

      • Volume

        Total project volume: approx. 642 T€ Sub-project volume: approx. 231 T€

    Funding

    Volume

    2020: Doctoral funding for Robert Mendel, funding program of the Bavarian State Ministry of Science and the Arts

    Project volume: approx. 281 T€

    2018: Funding program for applied research and development at universities of applied sciences - universities of applied sciences of the Free State of Bavaria

    Total project volume: approx. 642 T€ Sub-project volume: approx. 231 T€